发明名称 PROCESS FOR THE PREPARATION OF 2,4-DIAMINO-5-BENZYLPYRIMIDINES
摘要 The invention relates to a process for the preparaton of compounds of the formula I by reacting an alkali metal alcoholate with a compound of the formula II in the presence of an aliphatic ester such as methyl formate, and then condensing guanidine with the resulting compound of the formula III. The compound of the formula II can be prepared by reacting the corresponding benzaldehyde with acrylonitrile in the presence of diazabicyclo-2,2,2,-octane. <IMAGE> I <IMAGE> II <IMAGE> III
申请公布号 ZA8705689(B) 申请公布日期 1988.04.27
申请号 ZA19870005689 申请日期 1987.07.31
申请人 SOCIETE ANONYME: SANOFI PHARMA S.A.- SUCCURSALE DE CAROUGE 发明人 ABRAM BECKER
分类号 A61K31/505;A61P31/04;C07C255/53;C07D239/48;C07D239/49 主分类号 A61K31/505
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