COMPOUNDS AND METHODS TO INCREASE PLASMA HDL CHOLESTEROL LEVELS AND IMPROVE HDL FUNCTIONALITY
摘要
It has been discovered that certain selected ethers of probucol, and their pharmaceutically acceptable salts or prodrugs, are useful for increasing circulating HDL cholesterol. These compounds may also improve HDL functionality by (a) increasing clearance of cholesteryl esters, (b) increasing HDL-particle affinity for hepatic cell surface receptors or (c) increasing the half life of apoAI-HDL.
申请公布号
WO0177072(A3)
申请公布日期
2002.07.18
申请号
WO2001US11899
申请日期
2001.04.11
申请人
ATHEROGENICS, INC.;LUCHOOMUN, JAYRAZ;MENG, CHARLES, Q.;SAXENA, UDAY;SIKORSKI, JAMES
发明人
LUCHOOMUN, JAYRAZ;MENG, CHARLES, Q.;SAXENA, UDAY;SIKORSKI, JAMES