| 摘要 |
Provided is a compound showing a bone formation promoting action (and/or bone resorption suppressive action). A compound of the formula (I) or a pharmacologically acceptable salt:;;[wherein each substituent is as defined in the DESCRIPTION], has low toxicity, shows good pharmacokinetics, has an action to promote bone formation, and is useful for the prophylaxis or To treatment of metabolic bone diseases (osteoporosis, fibrous osteitis (hyperparathyroidism), osteomalacia, Paget's disease that influences the systemic bone metabolism parameter etc.) associated with a decrease in the bone formation ability as compared to the bone resorption capacity. |
| 主权项 |
1. A compound of the formula (I) or a pharmacologically acceptable salt: [wherein each substituent is as defined below R1: cyano group, C1-6 alkylcarbonyl group, C1-6 alkylcarbonylamino group, nitro group, halogeno C1-6 alkyl group, C2-6 alkenyl group, halogeno C2-6 alkenyl group, carbamoyl group, or hydroxy C1-6 alkyl group R2: C1-6 alkoxy group, carbamoyl group, C1-6 alkylaminocarbonyl group, or C1-6 alkylcarbonyl group R3: hydrogen atom, or halogen atom S, T and U: when any one of S, T and U is ═N—, others are ═CH— (═C— when R3 is substituted); or all of S, T and U are ═CH— (═C— when R3 is substituted) W: —NH—, —O—, or —S— X: single bond, -saturated heterocycle-, —CH2—(CH2)n—, —O—(CH2)n—, —(CH2)n—O—, or —CH═CH—(CH2)n— n: any one integer selected from 1-4 Y: single bond, —O—, or —CO— Z: hydrogen atom, saturated heterocyclic group optionally substituted by any group selected from substituent group α, or C1-6 alkyl group optionally substituted by any group selected from substituent group α substituent group α: saturated heterocyclic group, hydroxy C1-6 alkyl group, aminosulfonylamino group, carboxy group, hydroxy group, C1-6 alkoxy group, C1-6 alkyl group]. |
