Nanocapsules with a polymer shell

摘要

The invention relates to a system for administering active ingredients, including nanocapsules comprising an oil, a cationic surfactant and a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA) and polyasparagine (PAsn) or a combination of same and, optionally, an active ingredient, with the condition that when the polymer includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG) the active ingredient is not a didemnin or a tamandarin. The invention also relates to methods for obtaining said nanocapsule system, the pharmaceutical compositions thereof and the use of same in medicine.

主权项

1. A system for the administration of active ingredients comprising nanocapsules having a core comprising an oil and a cationic surfactant and a shell comprising a polymer selected from the group consisting of polyglutamic acid (PGA), polyglutamic-polyethyleneglycol acid (PGA-PEG), hyaluronic acid (HA), polyasparagine (PAsn), wherein the polyasparagine has approximately 5% of aspartic acid residues, and combinations thereof, and optionally an active ingredient, with the proviso that when said nanocapsules system includes polyglutamic acid or polyglutamic-polyethyleneglycol acid (PGA-PEG), then the active ingredient is not a didemnin or tamandarin, wherein the nanocapsules have a negative zeta potential ranging from −0.5 mV to −69 mV when measured in a dispersion of the nanocapsules in water.