主权项 |
1. A double-stranded ribonucleic acid (dsRNA) for inhibiting expression of transthyretin (TTR), wherein the dsRNA comprises a sense strand and an antisense strand, the antisense strand comprising a region complementary to a part of a mRNA encoding transthyretin (TTR), wherein the region of complementarity is less than 30 nucleotides in length and the antisense strand comprises 15 or more contiguous nucleotides of an antisense strand selected from Tables 3A, 3B, 4, 6A, 6B, 7, and 16 or SEQ ID NO:170, SEQ ID NO:450, SEQ ID NO:730, or SEQ ID NO:1010. |