NOVEL FORMS OF CLASS II MHC TRANSACTIVATOR (CIITA)

摘要

Novel deletion mutants of the class II transactivator protein (CIITA) are disclosed. Isolated DNA encoding such mutants are also disclosed, as are recombinant DNA vectors containing said DNA, and antibodies that specifically bind the mutant CIITA proteins. Additionally, methods of treating disorders characterized by abnormal expression of major histocompatibility complex (MHC) antigens by administering novel mutants of the present invention are also disclosed.