| 摘要 |
Small crystals are made by mixing a solution of a desired substance with an anti-solvent in a fluidic vortex mixer in which the residence time is less than 1 s, for example 10 ms. The liquid within the fluidic vortex mixer (12) is subjected to high intensity ultrasound from a transducer (20, 22) in or o n the wall of the mixer, or coupled to a pipe supplying liquid to the mixer. T he solution very rapidly becomes supersaturated, and the ultrasound can induce a very large number of nuclei for crystal growth. Small crystals, for example less than 5 .mu.m, are formed that may be of a suitable sise for use in inhalers.
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