| 发明名称 |
Antibodies Reactive with B7-H3 and Uses Thereof |
| 摘要 |
The present invention relates to antibodies that are immunoreactive to the mammalian, and more particularly, the human B7-H3 receptor and to uses thereof, particularly in the treatment of cancer and inflammation. The invention thus particularly concerns humanized B7-H3-reactive antibodies that are capable of mediating, and more preferably enhancing the activation of the immune system against cancer cells that are associated with a variety of human cancers. |
| 申请公布号 |
US2016264672(A1) |
申请公布日期 |
2016.09.15 |
| 申请号 |
US201615169211 |
申请日期 |
2016.05.31 |
| 申请人 |
MacroGenics, Inc. |
发明人 |
Johnson Leslie S.;Huang Ling;Moore Paul A.;Loo Deryk T.;Chen Francine Zhifen |
| 分类号 |
C07K16/28;C07K16/30 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A nucleic acid molecule comprising a sequence encoding a polypeptide comprising:
(A) a light chain having the amino acid sequence of SEQ ID NO: 117; or (B) a heavy chain having the amino acid sequence of SEQ ID NO: 119. |
| 地址 |
Rockville MD US |
