发明名称 |
SUBSTITUTED OXASOLIDINONES AND THEIR USE |
摘要 |
N-oxazolidinylmethyl-substituted (benzo)thiophene carboxamides (I) and their salts, hydrates and prodrugs are new. N-oxazolidinylmethyl-substituted (benzo)thiophene carboxamides of formula (I) and their salts, hydrates and prodrugs are new. [Image] R 1> : optionally benzo-fused thiophene, optionally substituted one or more times; R 2> : any selected organic group; R 3>-R 8> : same or different hydrogen or 1-6C alkyl. Excluded are compounds where R 2> = phenyl (optionally substituted once or more) and all of R 3>-R 8> are hydrogen. Independent claims are also included for the following: (1) preparation of (I); and (2) pharmaceutical composition containing (I), optionally also auxiliaries and carriers. ACTIVITY : Anticoagulant; cardiant; anti-anginal; vasotropic; thrombolytic; cerebroprotective; antiarthritic; antiarteriosclerotic; cytostatic; nootropic; neuroprotective. Test details are described but no results given. MECHANISM OF ACTION : Coagulation factor Xa Inhibitor. |
申请公布号 |
HRP20060251(B1) |
申请公布日期 |
2016.08.12 |
申请号 |
HR2006P000251 |
申请日期 |
2006.07.18 |
申请人 |
Bayer Intellectual Property GmbH |
发明人 |
Straub, Alexander;Lampe, Thomas;Pohlmann, Jens;Röhrig, Susanne;Perzborn, Elisabeth;Schlemmer, Karl-Heinz;Pernerstorfer, Joseph |
分类号 |
C07D413/14;A61K31/42;A61K31/422;A61K31/423;A61K31/424;A61K31/427;A61K31/428;A61K31/4365;A61K31/444;A61K31/454;A61K31/496;A61K31/5355;A61K31/5377;A61K31/538;A61K31/5383;A61K31/541;A61P7/00;A61P7/02;A61P9/10;A61P19/02;A61P25/28;A61P35/00;A61P43/00;C07D413/12;C07D417/14;C07D495/04;C07D498/04 |
主分类号 |
C07D413/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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