| 摘要 |
FIELD: organic chemistry, pharmacy. SUBSTANCE: sulfides, sulfoxides or sulfones of the formula (I) <EMI ID=0.279 HE=21 WI=42 TI=CHI> where X - carbonyl or a residue of the formula (II) <EMI ID=0.280 HE=15 WI=24 TI=CHI>; R<SB>5</SB> - hydrogen atom or alkyl; Y - C<SB>1-2</SB>-alkylene chain; Z - C<SB>2-53</SB>-alkylene chain possibly substituted with alkyl; R - a residue of the formula (III) <EMI ID=0.281 HE=18 WI=18 TI=CHI> where R<SB>3</SB> - halide; R<SB>4</SB> - H or halide, or R<SB>3</SB> and R<SB>4</SB> in common with carbon atoms to which they bound form the condensed benzene ring; R<SB>1</SB> and R<SB>2</SB> - H, alkyl, phenylalkyl; m = 0, 1, 2; n = 3 or 4 and their pharmaceutically acceptable salts that show antidepressant activity and capability to inhibit dopamine uptake. EFFECT: pharmacological activity of compounds. 12 cl, 1 tbl, 21 ex
|
