| 摘要 |
<p>A compound comprising a superoxide oxidant or reductant to which is directly or indirectly linked an NO or NO2 group. More particularly, compounds having the formula: D-X-R, wherein R is a moiety that oxidizes and/or reduces superoxide to oxygen and/or hydrogen peroxide under physiological conditions; X is S, N, O or C; and D is NO or NO2. R can be a functionality containing an unpaired electron, a cation such as a physiologically acceptable metal ion, hydrogen or a protective group or R can be a complex of a transition metal and a macrocyclic ligand that dismutes superoxide under physiological conditions. These compounds can be used alone or in combination or concurrently with other therapeutic agents, particularly nitric oxide adducts. Further, the invention provides that the superoxide oxidants or reductants which have not been linked to an NO or NO2 group can be administered in combination or concurrently with nitric oxide or nitric oxide adducts. They are useful for preventing superoxide cell damage and for treating inflammatory disorders in mammals, particularly humans.</p> |
