Methods for manipulating phagocytosis mediated by CD47

摘要

Methods are provided to manipulate phagocytosis of cancer cells, including e.g. leukemias, solid tumors including carcinomas, etc.

主权项

1. A method of treating a human subject with a leukemia or lymphoma, the method comprising:
administering to a human subject in need thereof an antibody that disrupts the binding of CD47 with SIRPα, at a dose that achieves a depletion in leukemia or lymphoma cells by increasing phagocytosis of the leukemia or lymphoma cells.