Method For Producing Nitriles By Elimination Of Water From Aldehyde Oximes With Alkylphosphonic Anhydrides

摘要

The invention relates to a method for producing the nitrites of formula: R¹-CN by reacting aldehyde oximes (R¹CN-N-OH) with cyclic alkylphosphonic anhydrides at a temperature ranging from -100 to +120° C., wherein R¹ represents H, a linear or branched C₁-C₁₂ alkyl group, a C₃-C₁₀ cycloalkyl, alkenyl or an aryl or heteroaryl group. The cyclic phosphonic anhydride preferably used is a 2,4,6-substituted 1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide of formula (I), wherein R' independently represents allyl, aryl or open-chain or branched C₁ to C₁₂ alkyl groups. Optionally, the reaction can be carried out in the presence of a tertiary amine base NR²₃