NAPHTHYLOXYACETIC ACID DERIVATIVES AND DRUGS COMPRISING THE SAME AS ACTIVE INGREDIENTS

摘要

Naphthyloxyacetic acid derivatives represented by general formula (I), wherein A represents H, -(alkylene)COOR<1>, -(alkylene)CONR<2>R<3>, -(alkylene)OH, -(alkylene)tetrazolyl or -(alkylene)-CN; E represents a single bond or alkylene; G represents -S-, -SO-, -SO2-, -O- or -NR<4>-; L represents alkylene, -(CH2)m-CH=CH-(CH2)n- or -(CH2)x-CH(OH)-(CH2)y-; M represents phenyl, phenyl-(thio, oxy, amino), diphenylmethyl or diphenylmethyl(thio, oxy, amino). The compound (I) binds to PGE2 receptors and exhibit an antagonistic or agonistic effect thereon. Thus, it is useful as a hyperlipemia inhibitor, a medecine for preventing abortion, an analgetic agent, an antidiarrheal, a drug for sleep induction, a diuretic agent, an antidiabetic agent, an interrupting agent, a purgative, an antiulcer agent, a drug for gastritis, a hypotensive drug, etc.