| 发明名称 |
Multibinding inhibitors of cyclooxygenase-2 |
| 摘要 |
Disclosed are multibinding compounds which inhibit cyclooxygenase-2 (COX-2), an enzyme which catalyzes the first committed step in the biosynthesis of prostaglandins. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is a moiety capable of binding to COX-2. The multibinding compounds of this invention are useful in the treatment inflammation, pain, fever and the like. |
| 申请公布号 |
AU4428899(A) |
申请公布日期 |
1999.12.30 |
| 申请号 |
AU19990044288 |
申请日期 |
1999.06.07 |
| 申请人 |
ADVANCED MEDICINE, INC. |
发明人 |
J. KEVIN JUDICE;DEBORAH L. HIGGINS;JOHN H GRIFFIN |
| 分类号 |
C07D231/12;A61K31/00;A61K31/341;A61K31/40;A61K31/415;A61K47/48;A61P29/00;A61P43/00;C07B61/00;C07C233/36;C07C233/78;C07C237/24;C07C271/20;C07C321/04;C07C323/12;C07C335/08;C07C335/32;C07D207/32;C07D207/333;C07D211/58;C07D215/56;C07D233/90;C07D235/30;C07D307/58;C07D401/06;C07D401/12;C07D401/14;C07D405/04;C07D413/14;C07D471/04;C07D471/14;C07D473/00;C07D473/34;C07D475/04;C07D475/08;C07D487/04;C07D487/06;C07D493/04;C07D493/06;C07D498/04;C07D519/00;C07H19/20;C12Q1/26;C12Q1/44;C12Q1/48;C12Q1/533;C40B20/06;C40B30/04;C40B40/04;C40B50/08;G01N33/573;G01N33/68;G01N33/92 |
主分类号 |
C07D231/12 |
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