发明名称 |
IN VIVO MUTATIONS AND POLYMORPHISMS IN THE 17Q-LINKED BREAST AND OVARIAN CANCER SUSCEPTIBILITY GENE |
摘要 |
The present invention relates generally to the field of human genetics. Specifically, the present invention relates to methods and materials used to isolate and detect a human breast and ovarian cancer predisposing gene (BRCA1), some mutant alleles of which cause susceptibility to cancer, in particular breast and ovarian cancer. More specifically, the invention relates to germline mutations in the BRCA1 gene and their use in the diagnosis of predisposition to breast and ovarian cancer. The present invention further relates to somatic mutations in the BRCA1 gene in human breast and ovarian cancer and their use in the diagnosis and prognosis of human breast and ovarian cancer. |
申请公布号 |
WO9605306(A3) |
申请公布日期 |
1996.03.14 |
申请号 |
WO1995US10202 |
申请日期 |
1995.08.11 |
申请人 |
MYRIAD GENETICS, INC.;CENTRE DE RECHERCHE DU CHUL;CANCER INSTITUTE |
发明人 |
SHATTUCK-EIDENS, DONNA, M.;SIMARD, JACQUES;EMI, MITSURU;NAKAMURA, YUSUKE;DUROCHER, FRANCINE |
分类号 |
C12N15/09;A61K38/00;A61K38/17;A61K48/00;C07K14/47;C07K14/82;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/12;C12P21/02;C12Q1/68;G01N33/574 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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