发明名称 |
Identification of hop-1 and uses thereof |
摘要 |
This invention provides an isolated nucleic acid molecule which encodes a wildtype or mutated HOP-1. This invention also provides a purified wild-type HOP-1 protein or a purified mutated HOP-1 protein. This invention also provides a method for production of an antibody capable of binding to wild-type HOP-1 or mutated HOP-1 protein. This invention also provides an antibody capable of specifically binding to wild-type HOP-1 or mutated HOP-1. This invention also provides a transgenic animal comprising the isolated nucleic molecule encoding HOP-This invention also provides Caenorhabditis elegans mutants in the endogenous hop-1 gene and various method to produce such mutants. This invention also provides a method for identifying a compound which is capable of ameliorating Alzheimer's disease. This invention also provides a method for determining whether a compound is capable of ameliorating Alzheimer's disease. This invention also provides a method for producing suppressors of a hop-1 allele. This invention also provides a pharmaceutical composition effective in ameliorating Alzheimer's disease and methods of using such a pharmaceutical composition. |
申请公布号 |
AU9507898(A) |
申请公布日期 |
1999.04.12 |
申请号 |
AU19980095078 |
申请日期 |
1998.09.25 |
申请人 |
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK |
发明人 |
IVA GREENWALD;XIAJUN LI |
分类号 |
A61K38/00;A61K48/00;A61K49/00;C07K14/435;C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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