DIABETES MODEL MICE AND PREPARATION METHOD THEREOF

摘要

The present invention relates to a diabetic animal model by abnormal oxidative phosphorylation (OxPhos) of mitochondria, and a method for establishing the same and, more specifically, to a diabetic animal model characterized by being a mouse, of which the Crif1 gene is specifically knockout in beta cells. The purpose of the present invention is to provide an animal model useful for the research of the mechanism of diabetes and the efficacy test of diabetic medicines.