发明名称 |
Novel lapachone compounds and methods of use thereof |
摘要 |
The present invention provides novel tricyclic spiro-oxathiine naphthoquinone derivatives, a synthetic method for making the derivatives, and the use of the derivatives to induce cell death and/or to inhibit proliferation of cancer or precancerous cells. The naphthoquinone derivatives of the present invention are related to the compound known as beta-lapachone (3,4-dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione).
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申请公布号 |
US2009105166(A1) |
申请公布日期 |
2009.04.23 |
申请号 |
US20070894900 |
申请日期 |
2007.08.21 |
申请人 |
ASHWELL MARK A;TANDON MANISH;LAPIERRE JEAN-MARC;ALI SYED;VENSEL DAVID;LI CHIANG J |
发明人 |
ASHWELL MARK A.;TANDON MANISH;LAPIERRE JEAN-MARC;ALI SYED;VENSEL DAVID;LI CHIANG J. |
分类号 |
A61K31/704;A61K31/337;A61K31/39;A61K31/4196;A61K31/4375;A61K31/438;A61K31/44;A61K31/4535;A61K31/505;A61K31/517;A61K31/519;A61K31/5377;A61K31/55;A61K31/566;A61K31/675;A61K31/7068;A61P35/00;C07D327/06;C07D497/10 |
主分类号 |
A61K31/704 |
代理机构 |
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地址 |
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