| 主权项 |
1. A compound of the general formula (I), its tautomeric form, its stereoisomer, or its pharmaceutically acceptable salt, wherein, M is selected from C, CH, and N; is a single bond when M is selected as N, and is either a single or a double bond when M is selected as CH or C respectively; R1 is selected from hydrogen, and substituted- or unsubstituted-alkyl; R2 and R3 groups are attached either to the same carbon atom or adjacent or non-adjacent carbon atoms of the carbocylic ring, and R2 and R3 together with the carbon atom(s) to which they are attached form a substituted- or unsubstituted carbocycle; R4 is selected independently at each occurrence from halogen, cyano, substituted- or unsubstituted-alkyl, —OR9, and —N(R10)R11; R5 and R6 are each independently selected from hydrogen, halogen, substituted- or unsubstituted-alkyl, perhaloalkyl, substituted- or unsubstituted-cycloalkyl, —OR9, and —N(R10)R11, or R5 and R6 together constitute oxo (═O), or both R5 and R6 attached to the same carbon atom or adjacent or non-adjacent carbon atoms together with the carbon atom(s) to which they are attached form a substituted- or unsubstituted-carbocycle, or when they are attached to adjacent carbon atoms, form a pi bond linking the said carbon atoms. R7a, R8a, R7b, R8b, R7c, R8c,R7d, and R8d are each independently selected from hydrogen, halogen, substituted- or unsubstituted-alkyl, —OR9, and —N(R10)R11; or any two groups out of R7a, R8a, R7b, R8b, R7c, R8c, R7d, and R8d form oxo (═O), or any two groups out of R7a, R8a, R7b, R8b, R7c, R8c,R7d, and R8d taken together with the carbon atom(s) to which they are attached form a substituted- or unsubstituted-carbocycle, or a substituted- or unsubstituted heterocycle, thereby making ring ‘A’ either a spiro-bicycle or a fused-bicycle or a bridged-bicycle; Ar is selected from substituted- or unsubstituted-aryl and substituted- or unsubstituted heteroaryl; p is an integer selected from 0, 1, 2 and 3; n is an integer selected from 1, 2, 3, and 4; R9 is selected from hydrogen and substituted- or unsubstituted-alkyl; R10 and R11 are each independently selected from hydrogen and substituted- or unsubstituted-alkyl; when an alkyl group or alkenyl group is substituted, each of them is substituted with 1 to 4 substituents independently selected from oxo (═O), halogen, cyano, perhaloalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, —OR12a, —SO2(alkyl), —C(═O)O(alkyl), —C(═O)N(H)R12,—C(═O)N(alkyl)2, —N(H)C(═O)(alkyl), —N(H)R12, and —N(alkyl)R12; when ‘cycloalkyl’, ‘cycloalkenyl’ and ‘carbocycle’ is substituted, the cycloalkyl, cycloalkenyl, or carbocycle group is substituted with 1 to 4 substituents independently selected from oxo (═O), halogen, cyano, alkyl, alkenyl, perhaloalkyl, —OR12, —SO2(alkyl), —C(═O)O(alkyl), —C(═O)N(H)R12, —C(═O)N(alkyl)R12, —N(H)C(═O)(alkyl), —N(H)R12, and —N(alkyl)2; when the aryl group is substituted, it is substituted with 1 to 4 substituents independently selected from halogen, nitro, cyano, hydroxy, alkyl, alkenyl, perhaloalkyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, —O-alkyl, —O-perhaloalkyl, —N(alkyl)alkyl, —N(H)alkyl, —NH2, 13 SO2-alkyl, —SO2-perhaloalkyl, —N(alkyl)C(═O)alkyl,—N(H)C(═O)alkyl, —C(═O)N(alkyl)alkyl, —C(═O)N(H)alkyl, —C(═O)N(H)cycloalkyl, —C(═O)NH2, —SO2N(alkyl)alkyl, —SO2N(H)alkyl, —SO2NH2, —C(═O)OH, —C(═O)O-alkyl, —O(C═O)N(alkyl)H, —O(C═O)N(alkyl)2, —O(C═O)N(cycloalkyl)H, —N(H)C(═O)N(aryl)H, —N(H)C(═O)N(alkyl)H, and —N(H)C(═O)NH2; when the heteroaryl group is substituted, it is substituted with 1 to 4 substituents independently selected from halogen, nitro, cyano, hydroxy, alkyl, alkenyl, perhaloalkyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl, heteroaryl, —O-alkyl, —O-perhaloalkyl, —N(alkyl)alkyl, —N(H)alkyl, —NH2, —SO2-alkyl, —SO2-perhaloalkyl, —N(alkyl)C(═O)alkyl, —N(H)C(═O)alkyl, —C(═O)N(alkyl)alkyl, —C(═O)N(H)alkyl, —C(═O)N(H)cycloalkyl, —C(═O)NH2, —SO2N(alkyl)alkyl, —SO2N(H)alkyl, —SO2NH2, —C(═O)OH, —C(═O)O-alkyl, —O(C═O)N(alkyl)H, —O(C═O)N(alkyl)2, —O(C═O)N(cycloalkyl)H, —N(H)C(═O)N(aryl)H, —N(H)C(═O)N(alkyl)H, and —N(H)C(═O)NH2; when the heterocyclic group is substituted, it is substituted either on a ring carbon atom or on a ring hetero atom, and when it is substituted on a ring carbon atom, it is substituted with 1 to 4 substituents independently selected from oxo (═O), halogen, cyano, alkyl, alkenyl, perhaloalkyl, —OR12, —SO2(alkyl), —C(═O)O(alkyl), —C(═O)N(H)R12, —C(═O)N(alkyl)R12, —N(H)C(═O)(alkyl), —N(H)R12, and —N(alkyl)2; and when the heterocyclic group is substituted on a ring nitrogen, it is substituted with substituents independently selected from alkyl, alkenyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, —SO2(alkyl), —C(═O)(alkyl), C(═O)O(alkyl), —C(═O)N(H)R12, and —C(═O)N(alkyl)R12; R12 is selected from hydrogen and alkyl; and R12a is selected from hydrogen, alkyl, alkenyl, and perhaloalkyl. |
