MICRONIZED OPIOID COMPOSITIONS, FORMULATIONS AND DOSAGE FORMS AND METHODS OF MAKING THE SAME

摘要

PROBLEM TO BE SOLVED: To provide novel compositions, formulations and dosage forms comprising stabilized micronized opioid particles.SOLUTION: Exemplary opioids comprise oxycodone, oxymorphone, hydrocodone, and hydromorphone, as free bases or as salts. Stabilized micronized opioid particles having a Dv90 particle size distribution of less than or equal to 10 μ or less than or equal to 20 μ are disclosed. A method for micronizing an opioid to provide stabilized micronized opioid particles is also disclosed.SELECTED DRAWING: None