NOVEL THIOPHENE DERIVATIVES AND DRUG COMPOSITIONS CONTAINING THE SAME

摘要

A thiophene derivative represented by the following general formula (I) or a pharmaceutically acceptable salt thereof <CHEM> (each symbol in the above formula means as follows, R1: formula -A1-X1-R3, R2: formula -A2-X2-R4 or does not exist, B ring: 1) 4- to 10-membered nitrogen-containing cycloalkyl ring, or 2) 5- or 6-membered nitrogen-containing unsaturated heterocycle, Ar ring: an aryl ring which may have a substituent, or a 5- or 6-membered aromatic heterocycle or an 8- to 10-membered aromatic bicyclic heterocycle, which contains 1 to 4 of one or more types of hetero atoms selected from the group consisting of a nitrogen atom, an oxygen atom and a sulfur atom, A1, A2 and A3: the same or different from one another, and each represents a bond or a lower alkylene group, X1 and X2: the same or different from each other, and each represents a bond or a formula -O-, -S-, -NR5-, <CHEM> R5, R6, R7, R8, R9, R10, R11, R12 and R13: the same or different from one another, and each represents a hydrogen atom or a lower alkyl group, and R3 and R4: the same or different from each other, and each represents a hydrogen atom, a cyclic imido group which may have a substituent and may be condensed with a benzene ring, or a lower alkyl group, a cycloalkyl group, an aryl group or an aralkyl group, which may respectively have a substituent, with the proviso that, when Ar ring is thiazole ring, either one of A1 and A2 is a lower alkylene group, and when Ar ring is a benzene ring, a case in which R1 and R2 is methyl group or a halogen group and the other is a hydrogen atom is excluded).