Oxazolidine derivatives and pharmaceutically acceptable salts thereof

摘要

PCT No. PCT/JP93/00559 Sec. 371 Date Dec. 21, 1993 Sec. 102(e) Date Dec. 21, 1993 PCT Filed Apr. 28, 1993 PCT Pub. No. WO93/22298 PCT Pub. Date Nov. 11, 1993.An oxazolidine derivative represented by the formula (I) <IMAGE> wherein R1, R2 and R3 are H, optionally halogenated alkyl, optionally halogenated alkoxy, OH, halo, NO2, amino optionally having acetyl or alkyl, COOH, alkoxycarbonyl, CN, alkanoyl, 2-oxazolyl, or R1 and R2 may be combined with each other to represent -(CH2)p- or -O(CH2)qO- (p is 3-5, q is 1-3) to form a ring, m and n are each 0 or 1, R4 and R5 are H or alkyl, X is C or N, Y is CH2OH, CHO or COOR6 (R6 is alkyl, benzyl or H), A is alkylene, carbonyl or sulfonyl, B is alkylene, E is alkylene which may be substituted with halo or is alkenylene, Z is O or S, except for a compound wherein n is 0, m is 1 and Y is CH2OH, and except for a compound wherein n is 0, Y is COOR6 (R6 is alkyl), a salt thereof, a process for its preparation, anti-hyperlipidemic composition containing the derivative as an active ingredient and a method for treating hyperlipidemia comprising administering the derivative.