N-substituted quinoline derivatives, process for their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them.

摘要

Product of formula (ID): in which: D1, D2, D3 and D4 nitrogen, methine or methylene, R1B hydrogen, alkyl, alkenyl, alkynyl, acyl, cyano or carboxy, RB, R2B and R3B: a) hydrogen, halogen, hydroxyl, mercapto, cyano, nitro, sulpho, formyl, benzoyl, acyl, carboxy or cycloalkyl, b) alkyl, alkenyl, alkynyl, alkyloxy, alkylthio, c) aryl, arylalkyl, arylalkenyl, aryloxy or arylthio d) R5B alkylene, YB represents -Y1B-B-Y2B: Y1B represents aryl B represents: either a single bond between Y1B and Y2B, or: -CO-, -NH-CO-, -CO-NH-, -O-(CH2)n- or -S-(CH2)n- (n = 0 to 4), Y2B represents: either, if B represents a single bond, hydrogen, halogen, hydroxyl, cyano, nitro, trifluoromethyl, carboxy, tetrazole or isoxazole, or, irrespective of the nature of B, Y1B. These products justify their use as pharmaceuticals.