| 摘要 |
PCT No. PCT/US91/05887 Sec. 371 Date Mar. 16, 1993 Sec. 102(e) Date Mar. 16, 1993 PCT Filed Aug. 19, 1991 PCT Pub. No. WO92/03420 PCT Pub. Date Mar. 5, 1992.Compounds of formula (I), <IMAGE> I in which R1 and R2, which may be the same or different, represent hydrogen, C1-6 alkyl, R3 and R4 independently represent one or more radicals selected from hydrogen, OH, NH2, NO2, halogen, C1-6 alkyl or C1-6 alkoxy and n is an integer from 1-2 inclusive, and pharmaceutically acceptable derivatives thereof are useful as pharmaceuticals; in particular, they possess N-methyl-(d)-aspartate(NMDA) blocking properties and are useful in the treatment and/or prevention of neurodegenerative conditions.
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