MTKI QUINAZOLINE DERIVATIVES.

摘要

The present invention concerns the compounds of formula (I) the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Y represents -C_3-9alkyl-, -C_1-5alkyl-NR6-C_1-5alkyl- or -C_1-5alkyl-NR7-CO-C_1-5alkyl-; X1 represents -O-; X2 represents NR5-C_1-2alkyl-; R1 represents hydrogen, halo or Het3-O-; R2 represents hydrogen; R3 represents hydroxy, C_1-4alkyloxy- or C_1-4alkyloxy subst ituted with one or two substituents each independently selected from Het4, hydroxy, C_1-4alkyloxy-, C_1-4alkyloxy-C_1-4alkyloxy and NR9R10; R5 represents hydrogen or C_1-4alkyl; R6 represents hydrogen or C_1-4alkyl; R7 represents hydrogen; R9 and R10 each independently represent hydrogen; C_1-4alkyl-S(=O)₂-C_1-4alkyl-C(= O)-; C_1-4alkyl or C_1-4alkyl substituted with hydroxy; Het3 represents pyridinyl optionally substituted with C_1-4alkyl; Het4 represents morpholinyl, piperidinyl or piperazinyl wherein said Het4 is optionally substituted with hydroxy-C_1-4alkyl or C_1-4alkyl-S(=O)₂-C_1-4alkyl-.