| 发明名称 |
ANTI-INTERFERON-.ALPHA. ANTIBODIES |
| 摘要 |
The present invention relates generally to the generation and characterization of neutralizing anti-IFN-.alpha. monoclonal antibodies with broad reactivity against various IFN-.alpha. subtypes. The invention further relates to the use of such anti-IFN-.alpha. antibodies in the diagnosis and treatment of disorders associated with increased expression of IFN-.alpha., in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (IDDM) and systemic lupus erythematosus (SLE). |
| 申请公布号 |
CA2437161(C) |
申请公布日期 |
2016.06.07 |
| 申请号 |
CA20022437161 |
申请日期 |
2002.01.29 |
| 申请人 |
GENENTECH, INC. |
发明人 |
CHUNTHARAPAI, ANAN;KIM, JIN K.;PRESTA, LEONARD G.;STEWART, TIMOTHY |
| 分类号 |
C12N15/13;G01N33/53;A61K39/395;A61P3/10;A61P5/14;A61P5/50;A61P17/00;A61P37/02;A61P37/06;C07K16/24;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/16;C12N5/20;C12N15/02;C12N15/09;C12P21/02;C12P21/08;G01N33/564;G01N33/577;G01N33/68 |
主分类号 |
C12N15/13 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
