MAMMALION HAEMOGLOBIN COMPATIBLE WITH BLOOD PLASMA, CROSS-LINKED AND CONJUGATED WITH POLYALKYLENE OXIDES AS ARTIFICIAL MEDICAL OXYGEN CARRIERS, PRODUCTION AND USE THEREOF

摘要

The invention relates to covalently cross-linked mammalian haemoglobin which is covalently bonded to polyalkylene oxides. Said haemoglobin is, surprisingly, compatible with human or animal plasma proteins. The invention further relates to the production of said haemoglobin which is cross-linked and bonded to polyalkylene oxides, in addition to the use thereof as an artificial intra-vascular oxygen carrier in human and animal organisms or in individual organs.