发明名称 Polymeric thiol-linked prodrugs
摘要 Thiol-linked polymeric prodrugs and methods of making and using the same are disclosed. The use of a sulfhydryl bond as the basic link for linking the polymer to the drug allows a prodrug to be formed which takes advantage of plasma enzymes in vivo. A preferred conjugate is Methods of preparing and treatment are also disclosed.
申请公布号 US7033583(B2) 申请公布日期 2006.04.25
申请号 US20020290695 申请日期 2002.11.08
申请人 ENZON PHARMACEUTICALS, INC. 发明人 CHOE YUN H.;GREENWALD RICHARD B.
分类号 A61K31/74;A61K31/19;A61K31/198;A61K31/34;A61K31/401;A61K31/505;A61K31/7016;A61K31/7076;A61K31/75;A61K47/48;A61P35/00;A61P35/02;A61P37/06;A61P43/00;C08F2/00;C08G63/46;C08G63/685;C08G63/688 主分类号 A61K31/74
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