SYSTEM AND METHOD FOR DATA MINING VERY LARGE DRUGS AND CLINICAL EFFECTS DATABASES
摘要
A current system allows data-driven hypothesis generation to identify therapeutic candidates for a disease phenotype treatment by identifying drugs and clinical indications associated with lower occurrences of disease-associated phenotype(s) by a drug/drug class. A current system may include a pharmaceutical hierarchical ontology; a phenotype hierarchical ontology; a record database comprising clinical event records; a database mining engine; and a mapping engine. The database mining engine may iteratively progress through a portion of the pharmacological hierarchical ontology and phenotype hierarchical ontology to iteratively select pairs of cohort entries from each ontology; and for each pair of cohort entries, query the clinical record database for matching records. The mapping engine may map each pair of cohort entries into a matrix comprising a drug-event cell for each pair and apply a value thereto representing the number of database records matching items returned by the database mining engine for the corresponding cohort entries.
申请公布号
WO2016112025(A1)
申请公布日期
2016.07.14
申请号
WO2016US12208
申请日期
2016.01.05
申请人
CHILDREN'S HOSPITAL MEDICAL CENTER
发明人
ARONOW, BRUCE;SARANGDHAR, MAYUR;TABAR, SCOTT CARL;JEGGA, ANIL GOUD