发明名称 |
Method of magnetic resonance investigation of a sample using a hyperpolarised solution of a high T1 agent |
摘要 |
A method of magnetic resonance investigation of a sample such as from a human or non-human animal body comprises: (i) producing a hyperpolarised solution of a high T1 agent by dissolving in a physiologically tolerable solvent a hyperpolarised solid sample of the high T1 agent; (ii) where the hyperpolarisation of the solid sample of the high T1 agent in step (i) is effected by means of a polarising agent, separating the whole, substantially the whole, or a portion of the polarising agent from the high T1 agent; (iii) administering the hyperpolarised solution to the sample; (iv) exposing the sample to radiation of a frequency selected to excite nuclear spin transitions in the MR imaging nuclei of the high T1 agent; (v) detecting magnetic resonance signals from the sample and (vi) optionally generating an image, dynamic flow data, diffusion data, perfusion data, physiological data or metabolic data from the detected signals. A high T1 agent will be enriched with MR imaging nuclei with respect to the natural abundance of the nuclei in the molecules and can be C13 enriched at one or more carbonyl or quaternary carbon positions. The high T1 agent in the hyperpolarised solution has a T1 value (at a field strength in the range 0.01-5T and a temperature in the range 20-40oC) of at least 5 seconds
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申请公布号 |
NZ505151(A) |
申请公布日期 |
2002.11.26 |
申请号 |
NZ19980505151 |
申请日期 |
1998.12.23 |
申请人 |
AMERSHAM HEALTH AS |
发明人 |
HANSSON, GEORG;LEUNBACH, IB;PETERSSON, STEFAN;ARDENKJAER-LARSEN, JAN HENRIK;AXELSSON, OSKAR;GOLMAN, KLAES;WISTRAND, LARS-GORAN |
分类号 |
A61B5/055;A61B6/00;A61K49/00;A61K49/06;A61K49/08;A61K49/18;G01N24/08;G01R33/28;G01R33/48;G01R33/62;(IPC1-7):G01R33/28 |
主分类号 |
A61B5/055 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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