MORPHINE-6-GLUCURONIDE SYNTHESIS

摘要

The invention provides a novel method for synthesising M6G, and intermediates therefor. In order to synthesise M6G the major problem to overcome is to obtain the glycoside linkage with very high beta -selectivity since prior methods produce the alpha -anomer. The invention provides a method for the preferential synthesis of the beta -anomer of M6G which includes the step shown in Scheme 6: wherein use of DMAP is optional.