发明名称 |
VERFAHREN ZUR HERSTELLUNG VON NEUEN 1,2,4-OXADIAZIN-DERIVATEN |
摘要 |
5,6-Dihydro-4H, 1,2,4-oxadiazine derivs. of formula (I) and their acid-addn. and quat. salts are new. R1 is H or phenyl opt. subtd. by 1-4C alkyl, halogen, 1-4C alkoxy and/or NO2; R2 is 1-4C alkyl, 5-7C cycloalkyl, naphthyl, or phenyl opt. substd. as above; R3 is H, 1-4C alkyl or acyl; R4 is H or 1-4C alkyl and R5 is 5-7C cycloalkyl, 1-6C alkyl, or phenyl (1-4C alkyl) in which the phenyl gp. is opt. substd. by 1-4C alkoxy, halogen or NO2, or R4+R5 is -CH2CH2-Ar-CH2-, where Ar is 4,5-di-R6-1,2-phenylene and R6 is H or 1-4C alkoxy; m and n are 0-2. Intermediates obtd. in the prepn. of (I) are also new. 7 Cpds. (I) are specifically claimed including 3-phenyl-6- 3-phenyl-6-cyclohexylaminomethyl-5,6-dihydro-4H-1,2, 4-oxadiazine. (I) are powerful peripheral vasodilators and hypotensives, giving increased coronary blood flow, having milk antiinflammatory and diuretic activity, and having potent antiarrhythmic activity. |
申请公布号 |
DD153551(A5) |
申请公布日期 |
1982.01.13 |
申请号 |
DD19800224477 |
申请日期 |
1980.10.10 |
申请人 |
CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT,HU |
发明人 |
TAKACS,KALMAN,HU;KISS,ILONA,HU;SIMAY,ANTAL,HU;NAGY,PETER L.,HU;HETYEY,MARIA,HU;ECSERY,MARIAN,HU;SZEGI,JOZSEF,HU;VIRAG,SANDOR,HU;NAGY,SANDOR J.,HU |
分类号 |
A61K31/535;A61P7/10;A61P9/00;A61P9/08;A61P9/10;A61P9/12;A61P29/00;C07D273/04;C07D413/06;(IPC1-7):C07D273/04 |
主分类号 |
A61K31/535 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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