DC 107 DERIVATIVES (2)

摘要

DC 107 derivatives represented by general formula (I) or pharmacologically acceptable salts thereof, each having antibacterial and antitumor activities, wherein R1 represents CO(CR4AR4B)n1¢O(CH2)p1!n2OR5, wherein n1 represents an integer of 1 or 2; R4A and R4B are the same or different and each represents hydrogen or lower alkyl; p1 and n2 are each an integer of 1 to 10; and R5 represents hydrogen, lower alkyl, etc.; or formula (II), (wherein A1, A2, A3 and A4 are the same or different and each represents hydrogen, hydroxy, etc.); R2 represents hydrogen or COR6 (wherein R6 represents lower alkyl, aralkyl, optionally substituted aryl, etc.); R3 represents lower alkyl, lower alkenyl, aralkyl having optionally substituted aryl, alicyclic alkanoyloxy-alkyl, CH2OCOR7, etc., or R3 may form a bond together with Y; Y forms a bond together with R3 or Z; Z represents hydrogen or may form a bond together with Y; and W represents oxygen or NR8.