SOLID FORMS OF EMPAGLIFLOZIN

摘要

The invention relates to novel solid forms of empagliflozin of formula I, with the systematic name (2S,3R54R,5S,6R)-2-[4-chloro-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6- (hydroxy-methyl)oxane-3,4,5-triol. It deals with an amorphous or crystalline complex of empagliflozin with proline, a method of its preparation and use for the production of a drug form. The crystalline complex of empagliflozin with proline can be advantageously used to increase the purity of empagliflozin and its stabilization in terms of chemical and polymorphic purity. The invention further provides an amorphous form of empagliflozin and a method of its preparation.