发明名称 |
The 9,11-cycloendoperoxide prodrugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma |
摘要 |
<p>9,11 Cycloendoperoxide derivaties of biologically active prostaglandin analogs, and particulary of the ocular hypotensive drugs Bimatoprost, Latanaprost, Unoprostone, Travoprost and prostaglandin H<Sub>2</Sub> 1-ethanolamide or of structurally closely related analogs, are pro-drugs which hydrolyze under physiological conditions to provide prostaglandin analogues that are capable of providing sustained ocular and other in vivo concentrations of the respective drugs.
<Chemistry id="chema01" num="0001"><Image id="ia01" he="48" wi="107" file="IMGA0001.TIF" imgContent="chem" imgFormat="TIFF" /></Chemistry></p> |
申请公布号 |
EP1731516(A3) |
申请公布日期 |
2007.01.03 |
申请号 |
EP20060011653 |
申请日期 |
2003.08.04 |
申请人 |
ALLERGAN, INC. |
发明人 |
LING, KAH-HIING JOHN;YANG, WU;NI, JINSONG;YUAN, HAIQING;TANG-LIU, DIANE D. S. |
分类号 |
C07D317/06;A61K31/357;A61P1/04;A61P7/02;A61P9/12;A61P27/00;A61P27/02;A61P27/06;A61P29/00;A61P43/00 |
主分类号 |
C07D317/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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