CELLS LACKING B2M SURFACE EXPRESSION AND METHODS FOR ALLOGENEIC ADMINISTRATION OF SUCH CELLS

摘要

Disclosed herein are cells and populations of eel is comprising a genome in which the B2M gene has been edited to eliminate surface expression of MHC Class I protein in the cell or population of cells, and methods for allogeneic administration of such cells to reduce the likelihood that the cells will trigger a host immune response when the cells are administered to a subject in need of such cells.