| 发明名称 | Composition for controlled release of physiologically active substance | ||
| 摘要 | A composition for controlled release of a physiologically active substance can release a physiologically active substance in vivo at the desired timing. The composition includes an inner layer that is formed of a biodegradable substance that supports a physiologically active substance, and an outer layer that is formed of a biodegradable substance that differs from that of the inner layer. | ||
| 申请公布号 | US9446098(B2) | 申请公布日期 | 2016.09.20 |
| 申请号 | US201214358588 | 申请日期 | 2012.11.09 |
| 申请人 | National University Corporation University of Toyama | 发明人 | Nakaji Tadashi;Kitano Hiromi;Gujral Chirag Harsharan Singh |
| 分类号 | A61K9/16;A61K38/18;A61K9/50;A61K38/20;A61K38/30;A61K38/17 | 主分类号 | A61K9/16 |
| 代理机构 | Harness, Dickey & Pierce, P.L.C. | 代理人 | Harness, Dickey & Pierce, P.L.C. |
| 主权项 | 1. A composition for controlled release of a physiologically active substance comprising: an inner layer that is formed of a biodegradable substance that supports a physiologically active substance, and an outer layer that is formed of a biodegradable substance that differs from that of the inner layer, the composition being in a shape of particles, the inner layer being an approximately spherical core, and the outer layer being a layer that covers the core, the physiologically active substance being a protein, the biodegradable substance that forms the inner layer being a natural biopolymer, the protein being supported on the natural biopolymer via a chimeric protein that is synthesized by fusing a substance into the protein, the substance undergoing strong intermolecular interaction with the natural biopolymer, an association constant between the protein and the natural biopolymer being 108 to 1010 M−1, the outer layer allowing the physiologically active substance supported on the inner layer to pass therethrough when the inner layer has undergone biodegradation. | ||
| 地址 | JP | ||