PROCESS FOR THE FERMENTATIVE PREPARATION OF L-AMINO ACIDS USING CORYNEFORM BACTERIA

摘要

The invention relates to a process for the preparation of L-amino acids, in which the following steps are carried out, 7. [sic] a) fermentation of the desired L-amino acid- producing bacteria in which at least the glyA gene is attenuated, in particular by removal of the natural promoter, b) concentration of the desired product in the medium or in the cells of the bacteria and c) isolation of the L-amino acid, and optionally bacteria in which further genes of the biosynthesis pathway of the desired L-amino acid are addtionally amplified are employed, or bacteria in which the metabolic pathways which reduce the formation of the desired L-amino acid are at least partly eliminated are employed, and nucleotide sequences of the lacI-tac-5'glyA or lacI-tac-glyA unit.