| 摘要 |
<p>A biologically active proteinaceous composition comprising: a biologically active protein covalently attached to polyalkylene oxide, said polyalkylene oxide having a molecular weight of from about 1,000 to about 15,000 daltons and being comprised of monomethoxylated and non-methoxylated polyalkylene oxide such that less than about 10% w/w is non-monomethoxylated polyalkylene oxide is disclosed, together with a method for its preparation. Preferably the low diol polyalkylene oxide is polyethylene glycol having a preferred molecular weight of from about 4,000 to about 6,000 daltons and containing less than about 7% w/w non-methoxylated polyethylene glycol. Also disclosed is a method of treatment of disease processes associated with the adverse effects on tissue of superoxide anions, such as ischemic events, reperfusion injury, trauma and inflammation. <IMAGE></p> |
