| 摘要 |
Paramagnetic metal chelates of macrocyclic polyamino carboxylic derivatives (I) and their salts The carboxylic derivatives used to prepare the chelates are of formula (I), and their salts with bases. m = 1 or 2; R' = H, 1-4C alkyl or hydroxyalkyl, CH2-COOH, -CH2CONZ1Z2, or HOOC-CH-(CH2)m-CONHR1; Z1 and Z2 = H or 1-4C alkyl, optionally hydroxylated; R = a group of given formula (IV); a = 1 or 2; Z = a bond, CH2, CH2CONH, or (CH2)2NHCO; Z' = a bond, O, S, NQ, CH2, CO, CO-NQ, NQ-CO, NQ-CO-NQ-, or CO-NQ-CH2-CONQ; Z''' = CO-NQ, NQ-CO, CO-NQ-CH2-CONQ, or NQ-CO-CH2-NQ-CO; Q = h or 1-4C alkyl, optionally hydroxylated; R1 - R5 = H, Br, Cl, I, CO-NQ1Q2, or N(Q1)-CO-Q2; Q1 and Q2 = 2-6C alkyl, optionally hydroxylated and optionally interrupted buy O, such that Q1 and Q2 between them 4 - 10 OH groups, with the proviso that at least 1 and at most 2 of the groups R1 - R5 are amides The paramagnetic metal used to prepare the complexes is preferably gadolinium, especially Gd<3+>. Independent claim covers a scintigraphic product containing a radio-labelled chelate of (I). |
