| 摘要 |
PROBLEM TO BE SOLVED: To obtain a new compound useful as pharmaceutical intermediates, such as an intermediate for retinol (vitamin A). SOLUTION: This compound is expressed by formula I ([R is a protective group for H and OH; Y is expressed by formula II or III (R<1> to R<3> are each H or a 1-3C alkyl)], e.g. 1-acetoxy-3,7-dimethyl-9-(p-toluenesulfonyl)-9-(2,6,6- trimethyl-cyclohexen-1-yl)-nona-2,6-diene. A derivative expressed by formula I is obtained by making a basic compound (preferably, Grignard reagent) act on a compound expressed by Y-CH2 -SO2 Ar [Ar is an (substituted) aryl], reacting the product with an aryl halide expressed by IV (X is a halogen), and finally, reacting the resulting sulfone derivative expressed by formula V with a base (e.g. sodium hydroxide) in an organic solvent (e.g. n-hexane) at 40-50 deg.C for 1-24 hr. The quantity of the base to be used is normally 2-20 molar times as much as the derivative of formula V. |
