发明名称 |
CHIMERIC ANTIGEN RECEPTORS TARGETING B-CELL MATURATION ANTIGEN AND USES THEREOF |
摘要 |
The presently disclosed subject matter provides for methods and compositions for treating multiple myeloma. It relates to chimeric antigen receptors (CARs) that specifically target B cell maturation antigen (BMCA), and immunoresponsive cells comprising such CARs. The presently disclosed BMC A- specific CARs have enhanced immune-activating properties, including anti-tumor activity. |
申请公布号 |
WO2016090320(A1) |
申请公布日期 |
2016.06.09 |
申请号 |
WO2015US64112 |
申请日期 |
2015.12.04 |
申请人 |
MEMORIAL SLOAN-KETTERING CANCER CENTER;EUREKA THERAPEUTICS, INC. |
发明人 |
BRENT JENS, RENIER, J.;SMITH, ERIC, L.;LIU, CHENG |
分类号 |
C12N5/07;C07H21/04;C12P21/08 |
主分类号 |
C12N5/07 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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