| 摘要 |
Erythromycin derivatives or salt thereof having excellent antibacterial activity against atypical acid-fast mycobacteria and useful as antibacterial agent, which is represented by the following general formula: <CHEM> wherein, R<1> and R<2> represent hydrogen atom, an alkyl group, a homocyclic or heterocyclic group, an alkyl group substituted with a homocyclic group, or an alkyl group substituted with a heterocyclic group or the like, or R<1> and R<2> may combine to form a homocycle or a heterocycle, R<3> represents hydrogen atom or methyl group, R<4> represents hydroxyl group or the like; R<5> represents hydrogen atom, hydroxyl group or the like, R<6> and R<7> represent hydrogen atom, an alkyl group or the like; X represents NH or a group represented by N-O-R<8>, Y represents a group represented by O-C(=O)-R<9>, a cladinose derivative or the like, Z represents oxygen atom or sulfur atom, R<8> and R<9> represents an alkyl group, a homocyclic or heterocyclic group, an alkyl group substituted with a homocyclic group, or an alkyl group substituted with a heterocyclic group. |
