METHOD OF REGULATING MAMMALIAN TARGET-OF-RAPAMYCIN ACTIVITY BY INTERACTION BETWEEN PHOSPHOLIPASE D AND RAPTOR

摘要

The present invention relates to a method of regulating mammalian target-of-rapamycin (mTOR) by regulating a phospholipase D (PLD) activity that generates a complex with mTOR. Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.