发明名称 ARYL CARBAMATE OLIGOMERS FOR HYDROLYZABLE PRODRUGS AND PRODRUGS COMPRISING SAME
摘要 The present invention provides a compound having a formula: (I) where R<1> is selected from the group consisting of alkyl, -CH2(OC2H4)OCH3, and -(OC2H4)OCH3; n is 0-4; Olig is an oligomer having a formula (I) where L is a optional linker moiety selected from the group consisting of CH2O , CH2OX , OX , C(O) , C(O)X, NH , NHC(O) , XNHC(O) , NHC(O)X , C(O)NH , C(O)NHX , and (I), where X is alkyl1-6 or is not present, Y is N or O or is not present, and R<3> is alkyl1-6; PAG is a linear or branched polyalkylene glycol moiety; R<2> is an alkyl1-22 capping moiety if X is present or alkyl2-22 if X is not present; and q is a number from 1 to the maximum number of branches on PAG; and m is 1-5.
申请公布号 WO2005016240(A2) 申请公布日期 2005.02.24
申请号 WO2004US15004 申请日期 2004.05.06
申请人 NOBEX CORPORATION;EKWURIBE, NNOCHIRI N.;ODENBAUGH, AMY L. 发明人 EKWURIBE, NNOCHIRI N.;ODENBAUGH, AMY L.
分类号 A61K;C07C43/23;C07C45/67;C07C45/71;C07C47/575;C07C49/84;C07C235/48;C07C271/22;C07C271/28;(IPC1-7):A61K/ 主分类号 A61K
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