| 发明名称 |
METALLOPROTEASE INHIBITORS CONTAINING A SQUARAMIDE MOIETY |
| 摘要 |
<p>The present invention relates generally to pharmaceutical agents of Formula (I) containing a heterocyclic moiety, and in particular, to heterocyclic metalloprotease inhibiting compounds. More particularly, the present invention provides a new class of heterocyclic MMP 3, MMP 8 and/or MMP 13 inhibiting compounds with a squaramide or benzoxazinone moiety, that exhibit an increased potency and selectivity in relation to currently known MMP 13, MMP 8 and MMP 3 inhibitors. Formula (I).</p> |
| 申请公布号 |
WO2008109178(A1) |
申请公布日期 |
2008.09.12 |
| 申请号 |
WO2008US03192 |
申请日期 |
2008.03.07 |
| 申请人 |
ALANTOS PHARMACEUTICALS HOLDING, INC. |
发明人 |
GEGE, CHRISTIAN;CHEVRIER, CARINE;GALLAGHER, BRIAN, M., JR.;TAVERAS, ARTHUR |
| 分类号 |
C07D217/04;A61P19/00;C07D239/88;C07D401/12;C07D401/14;C07D403/12;C07D405/14;C07D409/12;C07D413/12;C07D413/14;C07D417/12;C07D471/02;C07D495/02;C07D495/20;C07D498/02 |
主分类号 |
C07D217/04 |
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