发明名称 |
TNFR:Fc融合タンパク質の安定した医薬液剤 |
摘要 |
The present invention relates to stable pharmaceutical liquid formulations of the fusion protein TNFR:Fc comprising different buffer systems and stabilizers. In particular, it could be demonstrated that the physical stability of TNFR:Fc is significantly improved by using a citrate buffer system and lysine as stabilizer. |
申请公布号 |
JP5996631(B2) |
申请公布日期 |
2016.09.21 |
申请号 |
JP20140505615 |
申请日期 |
2012.04.19 |
申请人 |
サンド・アクチエンゲゼルシヤフト |
发明人 |
ドイテル, ブリッタ;ラウバー, トーマス;フエルティンガー, ザビーネ |
分类号 |
A61K38/00;A61K9/08;A61K47/02;A61K47/10;A61K47/12;A61K47/18;A61K47/20;A61K47/32;A61K47/34;A61K47/36;A61K47/38;A61K47/42;A61P1/04;A61P11/06;A61P15/00;A61P17/02;A61P17/06;A61P19/02;A61P21/00;A61P25/28;A61P29/00;A61P31/14;A61P35/00;A61P37/00;A61P37/08 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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