Naphthalene derivatives processes for the preparation thereof and intermediates therefor

摘要

Naphthalene derivatives of the formula ÄIÜ: wherein R<1> and R<2> are the same or different and are each H, protected or unprotected OH, one of R<3> and R<4> is protected or unprotected hydroxymethyl, and the other is H, lower alkyl, or protected or unprotected hydroxymethyl, R<5> and R<6> are the same or different and are each H, substituted or unsubstituted lower alkyl, substituted or unsubstituted phenyl or protected or unprotected NH2, or both combine together with the adjacent N to form substituted or unsubstituted heterocyclic group, and pharmaceutically acceptable salts thereof, these compounds showing excellent bronchoconstriction inhibitory activity, and hence, being useful in the prophylaxis or treatment of asthma.