| 发明名称 |
Modulation of signal transducer and activator of transcription 3 (STAT3) expression |
| 摘要 |
Disclosed herein are antisense compounds and methods for decreasing STAT3 mRNA and protein expression. Such methods, compounds, and compositions are useful to treat, prevent, or ameliorate hyperproliferative diseases. |
| 申请公布号 |
US9359608(B2) |
申请公布日期 |
2016.06.07 |
| 申请号 |
US201414338880 |
申请日期 |
2014.07.23 |
| 申请人 |
ISIS Pharmaceuticals, Inc. |
发明人 |
Swayze Eric E.;Freier Susan M.;MacLeod Robert A.;Kim Youngsoo |
| 分类号 |
C07H21/02;C07H21/04;C12N15/113;C07H21/00;C12N15/00;C12N15/11 |
主分类号 |
C07H21/02 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A single-stranded modified oligonucleotide consisting of 12 to 30 linked nucleosides having a nucleobase sequence comprising at least 12 contiguous nucleobases of the nucleobase sequence of SEQ ID NO: 245, or a pharmaceutically acceptable salt thereof, wherein the oligonucleotide comprises at least one modified internucleoside linkage, and/or at least one a modified sugar, and/or at least one modified nucleobase. |
| 地址 |
Carlsbad CA US |
